Background: Maintaining a pleasant work environment and striking a healthy work-life balance are critical for improving employee well-being and performance. The Job Stress and Health model sheds light on acute challenges that employees confront as a result of numerous work-related or external variables. The COVID-19 epidemic has resulted in abrupt changes in work habits and lifestyles, resulting in severe stress and disruptions to people's physical and mental health around the world. Purpose: During the pandemic, this study was undertaken to investigate employee work pattern choices, such as work from home, blended work, or work from the office. Methods: This study examined how work pattern decisions affected HEI employees' well-being during the COVID-19 epidemic using the Job Stress and Health model and an online survey. To investigate work model preferences and challenges, demographics, work patterns, and well-being indicators including sleep and performance were collected and evaluated using descriptive and inferential statistics. The study questionnaire was close-ended and prepared in English. Results: Even after the pandemic, a significant proportion of employees preferred the blended work paradigm, showing the long-term impact of the shift in work habits. Furthermore, the shift in work schedules has had an impact on employee well-being, particularly changes in sleep patterns. Discussion: Even though the employees of higher education are adaptable and accept a blended work model, it is important to note that work-related stress and inefficiency can arise depending on the resource requirements. Also, physical and mental health aspects while working remotely or in a blended model need consideration, especially when implemented in the long term. Translation to Health Education Practice: Understanding the effects of these work pattern choices on employee well-being is critical for organizations to adopt policies that foster a healthy work environment and assist employees in reaching optimal work-life balance. A AJHE Self-Study quiz is online for this article via the SHAPE America Online Institute (SAOI) http://portal.shapeamerica.org/trn-Webinars. http://portal.shapeamerica.org/trn-Webinars