Design-based Research (DBR) focuses on real-world problems, emphasizes studying an educational intervention in its supposed context, uses a cyclical process of design, implementation, evaluation, and improvement, utilizes mixed research methods, stresses reciprocal relationships between theories and practice, and involves a close collaborative relationship between researchers and practitioners. Three iterative DBR research cycles were conducted on a project-based learning (PjBL) implementation in three population health nursing clinical PjBL blocks at a Midwest university. Data were collected at the end of each cycle through surveys, focus group interviews with students, faculty, and clinical agency contacts, as well as student work and performance. The data were analyzed, and revisions and improvements were planned for subsequent blocks and future use in the course.