The volatile, uncertain, complex and ambiguous future world has highlighted the importance of critical thinking, collaboration, communication, creativity and innovation (4Cs) in today's classrooms. Framed by the Partnership for 21st-Century Learning (P21) Learning and Innovation theme, the study investigates the perceptions of the 4Cs by secondary school students from four schools in Zimbabwe. Two hundred and thirty-six (236) students participated in this quantitative study. Data were collected using online and paper questionnaires. Exploratory and first-order confirmatory analysis revealed a four-factor model with excellent fit indices. The second-order confirmatory factor analysis confirmed that the individual 4Cs were sub-constructs of a higher latent factor, Learning and Innovation (4Cs), where the students strongly endorsed collaboration, followed by communication, critical thinking, creativity, and innovation in decreasing magnitude. Age has a significant influence on critical thinking. The findings highlight the need for teachers to embed critical thinking and creativity activities within collaborative and communication learning activities.