Adapted sports for people with physical disabilities have considerably increased over the last few years, highlighting benefits in health and quality of life of this population. However, no investigations have been conducted with this population in order to evaluate the relationship between quality of life and life style so far, particularly with respect wheelchair handball. This study aimed to examine the association between quality of life and lifestyle of wheelchair handball athletes. The cross-sectional study comprised a sample of 105 male athletes with physical disabilities. Participants provided answers to the questions of the sociodemographic questionnaire, WHOQOL-Bref scale and the Fantastic lifestyle assessment. To analyze the resulting data, a one-way ANOVA and Tukey's post hoc test were employed. The quality of life domains with higher and lower scores were, respectively, the "Psychological" and "Environmental." The lifestyle categories with higher and lower scores were related, respectively, to "Psychobiological Aspects" and "Work." The results evidenced an association between high quality of life and lifestyle scores, suggesting that the practice of adapted sports, and specifically wheelchair handball, can exert an important influence on the quality of life and lifestyle of people with physical disabilities.li