The purpose of this longitudinal investigation was to examine the effectiveness of a comprehensive, integrated curricular and co-curricular program designed to build community, provide academic and social support, and promote engagement in academically purposeful activities resulting in more equitable environments for historically underrepresented, low-income science, technology, engineering, and mathematics (STEM) information technology (IT) students. The study also focused on the role that the sense of belonging and academic hope play in enhancing persistence to degree completion. Program participants had significantly higher persistence rates compared to a matched comparison group. Additionally, STEM-specific belonging and academic hope significantly predicted students' intentions to persist to degree completion in IT. A major finding was that STEM domain--specific belonging was a stronger predictor of persistence than general belonging. Our investigation has implications for the role that cohort-based programs, industry engagement, peer mentoring, proactive advising, undergraduate research opportunities, career preparation, and leveraging need-based financial aid play in ensuring equity in STEM.