The Sustainable Development Goals (SDGs) are global action plans that aim to address various problems globally in the social, economic, cultural, energy, and environmental fields. One of the global problems is the significant open unemployment rate due to the gap between graduates and available jobs. Therefore, we need an innovation in learning to train students to develop their competencies. Competency development can be done through chemoentrepreneurship-based chemistry learning (CEP). CEP-based learning is chemistry learning through projects in product manufacturing and marketing. This study aims to measure students' social and vocational skills through CEP learning. This research was conducted at Islamic Senior High School in Rembang, Indonesia. The research subjects were 47 students. The results of the N-gain test showed that the social skills of the experimental and control groups experienced an increase in the low/effective less category. The N-gain value of the experimental group's social skills was 50.06, while the control group was 41.32. The results of the N-gain test for vocational skills in the experimental group were better than those in the control group. The increase in the vocational skills of the experimental group was in the medium/quite effective category (58.32), while the control group experienced a very low/ineffective increase in the category (33.47). [Note: The issue number (1) shown on the PDF is incorrect. The correct issue number is 2.]