The current review identified 11 single-case design (SCD) and 14 group-design evaluations of naturalistic behavioral interventions targeting prelinguistic social communication in young children with autism spectrum disorder (ASD). Three SCD studies and eight group design studies utilized methodologically rigorous designs and demonstrated a functional relation between the intervention and child prelinguistic social communication. Results of this systematic review provide information about efficacy of specific naturalistic behavioral interventions, details about the intervention, and characteristics of the implementation agent and setting. Such information may be useful to support implementation of evidence-based practices and increase the quality of future research.