This article makes the case for shifting the national focus from bullying prevention to the systemic integration of evidence-based practices of social and emotional learning (SEL) into US school programs and policies. Several meta-analyses demonstrate that SEL is a promising approach for reducing a range of disruptive behaviors in schools. The data also show that SEL enhances school engagement and climate, interpersonal relationships, well-being, and academic achievement. We critically analyze existing approaches to bullying prevention in the USA and, from a bioecological perspective, describe their limitations, in addition to the importance of emotions in the organization of children's development. We discuss why schools should address the social and emotional development of children and adults in order to decrease harmful behaviors, form positive relationships, support psychological health, and offer more effective education. The bioecological perspective provides a framework for successfully integrating whole-school, evidence-based approaches to SEL, including statewide adoption of SEL standards and increased focus on school climate.