Gamification is one of the innovative teaching approaches implemented in English classrooms nowadays. However, using gamification to enhance reading engagement and reading comprehension in language classrooms at the university level has not been much explored. This present study investigated gamification's effects on enhancing reading engagement, reading comprehension, as well as perceptions of gamification among Thai EFL university students. The participants in the research were 70 first-year students selected randomly. A mixed-methods research design was adopted to examine the effects of gamification between control and experimental groups. The quantitative results collected by the pre-test, posttest, pre-survey, and post-survey showed that the experimental group significantly improved reading comprehension and higher reading engagement after the implementation of gamification, compared to the control group that studied traditionally. Furthermore, the participants in the experimental group reported positive perceptions towards gamification, such as promoting reading engagement and creating a fun learning environment. Therefore, this study supports an alternative and innovative way to shift a reading class from a teacher-centered approach to a student-centered approach through gamification.