Although the swift proliferation of mobile technology has attracted considerable scholarly attention during the past few decades, relatively few studies have been devoted specifically to the potential influence of life satisfaction on mobile social media engagement among sojourning students. To address this research gap, the current study proposed a conceptual model to empirically explore how overall life satisfaction was associated with social comparison, fear of missing out and mobile social networking engagement. In a web-based survey, a total of 335 Chinese international students aged between 18 and 32 years old completed a battery of online questionnaires. Utilizing structural equation modeling, the results demonstrated that overall life satisfaction was negatively associated with users' mobile social media use intensity. Additionally, overall life satisfaction positively and significantly predicted both fear of missing out and negative social comparison. Furthermore, fear of missing out and negative social comparison could conceivably mediate the relationships between overall life satisfaction and mobile social media engagement. Therefore, the current article study may shed light on new directions for deeper understanding the underlying psychological mechanisms of mobile technology communication among sojourners and also of the comparatively new phenomenon of fear of missing out and negative comparison in contemporary mobile-saturated society.