Teachers are increasingly encouraged to creatively integrate technology into their classroom instruction as designers of technology-enhanced learning (TEL). However, they are often not competent in designing TEL due to their lack of experience as participatory designers as well as the ill-structure nature of TEL design problem. Design thinking, as a methodology and a framework for the design process, can serve as a guideline for the development of pre-service teachers' creativity. However, there is a lack of research investigating whether the strategies used in the empathizing stage of the design thinking process affect pre-service teachers' creativity differently. This study explored the effects of two commonly used empathy strategies, interview and observation, on pre-service teachers' creativity through a six-week learning design activity for pre-service teachers majoring in Science and Technology Education at a first-tier university in China. The results of this quasi-experimental research showed that the pre-service teachers using the interview empathy strategy performed better in creative problem-solving performance. While there was no significant difference in the pre-service teachers' creative thinking disposition between the two empathy strategies, the pre-service teachers using the interview strategy reported more positive creative confidence in their creativity than those using the observation strategy. This study suggests future research directions for supporting design thinking-based instructional design.