ERIC Number: EJ1407444
Record Type: Journal
Publication Date: 2024
Pages: 18
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0162-3257
EISSN: EISSN-1573-3432
Available Date: N/A
The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study
Yukihiko Shirayama; Kazuki Matsumoto; Fumio Osone; Akira Hara; Siqing Guan; Sayo Hamatani; Katsumasa Muneoka; Koichi Sato; Akihiro Okada; Tokuzou Yokokawa
Journal of Autism and Developmental Disorders, v54 n1 p193-210 2024
Proton magnetic resonance spectroscopy ([superscript 1]H-MRS) has shown inconsistent alterations in brain metabolites of adults with autism spectrum disorder (ASD). We investigated brain metabolites in the medial prefrontal cortex and amygdala of 24 drug-naive adults with ASD and no intellectual disability and 24 non-ASD control subjects, using 3 T[superscript 1]H-MRS. Adults with ASD showed no significant differences from control in glutamate, glutamate plus glutamine, N-acetylaspartate, glycerophosphorylcholine plus phosphorylcholine, creatine plus phosphocreatine, or myo-inositol in either region. However, ASD subjects did show significant correlations of localized brain metabolites with autistic traits, empathy deficits, and personality traits using the Autism-Spectrum Quotient, Questionnaire of Cognitive and Affective Empathy, Interpersonal Reactivity Index, and NEO Personality Inventory-Revised. These findings should be taken as preliminary or exploratory.
Descriptors: Brain, Brain Hemisphere Functions, Adults, Autism Spectrum Disorders, Personality Traits, Empathy, Symptoms (Individual Disorders)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Interpersonal Reactivity Index; NEO Personality Inventory
Grant or Contract Numbers: N/A
Author Affiliations: N/A