The aim of this study was to evaluate the efficacy of the youth version of the program Parents Taking Action in Bogota, Colombia, using a quasi-experimental design. We hypothesized that parents in the treatment groups would improve in levels of knowledge, empowerment, self-efficacy, and use of strategies related to topics of adolescence and sexuality compared to the control group. We recruited 25 Colombian parents of pre/adolescent youth with autism spectrum disorder between the ages of 10 and 17 in Bogota. The intervention included four weekly sessions in which the new content about sexuality and adolescence was delivered. Twelve parents were in the intervention group and 13 were in the control group. Intervention participants significantly improved in Knowledge (t = 4.37 p < 0.001), Self-Efficacy (t = 7.15, p < 0.001), Use of Strategies (t = 4.29, p < 0.001), and Family Empowerment (t = 3.82, p < 0.005) between baseline and follow-up. The control group did not improve on any of the outcome measures, and the mean differences between baseline and follow-up scores were significant between intervention and control groups. The program has potential for high impact as information is scarce and parents do not have resources related to pre/adolescence. The program shows promise as an efficacious tool for community organizations and health providers to support families.