Effective learning in schools can only be realized through the intervention of the principals since they are the leader. The principals with effective and efficient leadership present excellent contributions to school quality. This study assesses the principal's leadership in an inclusive high school in Padang, Indonesia. In addition to that, this study investigates the leadership of the school principal and effective learning. This study used a quantitative method and collected data through a questionnaire survey. From August to September 2018, the study lasted three to two months. This study included 100 students from 10 study groups at an inclusive state high school. In addition to the survey, we also collected data through interviews and documentation. Using the Stepwise method, multiple linear regression results were obtained; three of the four independent variables had a substantial effect on the successful learning practiced in school. From our findings, we concluded a connection between both the leadership of the school principal and the effective learning process. We also discovered a strong relationship involving both independent and dependent variables. Meanwhile, the effective learning process is determined substantially by the teachers' behavior during the learning process in the classroom at 83.40%.