Self-disgust is a complex emotion related to feeling aversion or revulsion about internal and personal physical attributes, personality, functioning and behaviours. The aim of the present study was to adapt, validate and examine the psychometric properties of the Multidimensional Self-Disgust Scale, in a sample of Portuguese adolescents (MSDS-A). Participants were 540 adolescents (n = 308 females, 57%), with ages between 13 and 18 years. Data were analysed through SPSS and MPLUS was used to perform a Confirmatory Factor Analysis (CFA). Self-report questionnaires were used to assess several indicators of psychopathology and self-compassion. Results from the CFA showed that a 4-factor model with a second order factor presented good fit indices. The full scale and its factors showed good internal consistency, adequate temporal stability, and good convergent, divergent and incremental validity. The MSDS-A seems a valid measure to assess self-disgust in adolescents, with important implications to clinical context and research.