Study Purpose: This study was undertaken to establish if the Holistic Wellness Assessment (HWA) can detect intra-individual changes following a 12-week undergraduate course in holistic wellness (N = 235). Methods: A single-group pretest post-test non-experimental design was used to evaluate changes in the eight HWA factors; concurrent collection of demographic variables enabled a limited moderation analysis. Results: Dependent t-tests adjusted for a false discovery rate revealed significant changes in six of the eight HWA factors indicating curriculum sensitivity in these HWA factors. Conclusions: Interpretations are offered at the HWA factor level that discuss relationships between curriculum activities and student artifacts with changes in factor and item responses over time. Using the HWA as a pre/post-test instrument helps instructors and students evaluate the changes that have been made as a result of the curriculum.