Social isolation can have a negative impact on well-being, yet important strengths can emerge in adversity. Our aim was to explore how pre-university students in Singapore responded to the social isolation caused by the COVID-19 pandemic. We conducted a thematic analysis of in-depth semi-structured interviews with six pre-university students (three males and three females). Singaporean pre-university students found a "lack of face-to-face contact" (Theme 1) with friends challenging. However, they utilised "acceptance" (Theme 2), and "adaptability and resilience" (Theme 3) to cope with the changes associated with the COVID-19 restrictions. Educators, counsellors, parents and researchers may better support pre-university students' well-being by discussing how to enhance the students' strengths, rather than solely attempting to alleviate negative mental health outcomes.