There is an increasing concern for self-care and quality of life among Master of Social Work (MSW) students as they prepare to serve vulnerable individuals, families, and communities. Evidence suggests numerous benefits to practicing self-care; however, the majority of these studies focus on practitioners in the helping professions as opposed to graduate students working toward their degrees, suggesting a need for research. Accordingly, this study investigates the association between self-care actions, distress tolerance, mindfulness and quality of life among MSW students. A cross-sectional survey design, was used to examine these associations among 148 MSW students. Three multiple regression analyses were conducted to determine the relationship among the key variables. Results suggest that emotional self-care was significantly associated with quality of life, and that the level of engagement in self-care actions differed across students' socioeconomic class. Students' mindfulness and emotional self-care also were positively associated with distress tolerance. Findings suggest that promoting engagement in emotional self-care and mindfulness self-care may promote higher quality of life among MSW students. Implications for MSW programs and the potential to support students' health and sustainable learning are discussed.