This brief report explores the associations of interpersonal strengths with subjective well-being and psychological flourishing among high-ability adolescents (M = 13.08, SD = 2.17) in Hong Kong during the COVID-19 pandemic outbreak. It also examines the indirect effects of strengths on well-being outcomes via satisfaction of basic psychological needs at school. Results demonstrated that love and leadership served as the most robust predictors of basic psychological needs satisfaction. Love was consistently associated with higher well-being outcomes. Whereas leadership was linked to higher levels of satisfaction with all dimensions of basic needs, this strength was related to lower levels of emotional well-being. Further, love, social intelligence, leadership, and kindness had indirect effects on life satisfaction, positive emotions, and flourishing via the satisfaction of basic needs for autonomy, relatedness, and competence. This research showcases the mental health benefits of selected interpersonal strengths during the pandemic outbreak.