Rooted in the decent education as a precursor to decent work, this study investigated via network analysis the relationship between the work as meaning inventory for university students (WAMI-U) (positive meaning, meaning-making through study, greater good motivations) and the humor styles questionnaire (HSQ) (health-promoting styles: affiliative humor, self-enhancing humor; health-endangering styles: aggressive humor, self-defeating humor) in 371 Italian university students. Central nodes and bridge nodes between WAMI-U and HSQ were calculated. Positive meaning, meaning-making through study (WAMI-U), and self-enhancing humor (HSQ) had high centrality. Affiliative humor, self-enhancing humor (HSQ), and positive meaning (WAMI-U) had bridge function. The high centrality and bridge function of self-enhancing with all dimensions of WAMI-U, followed by the bridge function of affiliative humor in relation to meaning-making through study (WAMI-U) confirmed them as health-promoting styles. Negative associations between maladaptive humor styles and positive meaning (WAMI-U) confirmed their standard as health-endangering styles. Implications for research and prevention are discussed.