This survey research investigated the factors influencing enrolments and study completion rates of persons with physical impairments in two government universities of Karachi. The population of the study consisted of non-students with physical impairments and university students with physical impairments. The sample of the study consisted of 20 non-students and 20 university students. Snowball sampling was used to collect the sample. Two structured questionnaires were developed to collect the data. Data analysis was conducted in the form of frequency tables. Results indicated that environmental factors (85%), academic grades (85%), transport factors (85%) and financial factors (90%) influenced enrolments rates of non-students in universities while environmental factors (75%), transport factors (75%), financial factors (90%) and lack of interest (90%) and will (90%) influenced study completion rates of university students. It is suggested to make the environment accessible, provide academic support, develop accessible transport, poverty reduction strategies and self-motivation in these persons.