While the multiliteracies framework proposed two decades ago has had a considerable effect on the field of second language (L2) teaching and learning, its successful implementation has been found challenging, both on the conceptual and practical levels. In this paper, we discuss the main hurdles of putting the approach into practice and argue for the use of the genre-based instruction in combination with key constructs of systemic functional linguistics (SFL) as a framework that can help address these challenges. Connecting the multiliteracies pedagogy with the genre-based approach, we delineate specifically how the literacy pedagogy moves and knowledge processes that constitute them can be implemented in content- and language-integrated L2 instruction. We illustrate the approach by reporting on the materials development project that focuses on a particular public discourse theme (banning the burka in Austria) and advanced literacy genre (Argumentative Discussion). The project serves as an example of formulating the advanced L2 learning goals and designing activity types that can be used for developing the multiliteracies curricula in other instructional and thematic contexts.