Objective: To examine how screening, brief intervention and referral to treatment (SBIRT) influenced nurses' knowledge, attitude, responsibility and confidence when caring for college students using electronic cigarettes (EC). Participants: Nurses (n = 8) in an urban university campus in the US. Methods: Training sessions included classroom instruction on SBIRT and EC, and practice with a standardized patient. Surveys administered pre and post training, and at conclusion. Measurement included nurse's knowledge of SBIRT and EC; and attitude, confidence and responsibility when using SBIRT. Students with past 90-day EC use were administered SBIRT by nurses and referred to health educator on request. Results: Over 6 weeks, 103 students reported EC use, 80 received SBIRT and 36 were referred to health educator. Nurses gained knowledge, supported using SBIRT, and reported that skills increased. Conclusions: SBIRT is a motivational interviewing skill that nurses can learn to use to engage with college students who use EC.