The development of multidisciplinary education requires people to communicate, learn, and design beyond the boundaries of their own domains. In this research, an education design framework is developed to facilitate and support university teachers in multidisciplinary educational design. In addition, it serves as an aid to potentially transform domain-specific action-oriented knowledge into domain-integrated action-oriented knowledge by supporting knowledge co-construction across domain boundaries. The educational design framework, grounded in seamless and hybrid learning paradigms and theory on wicked problem solving, is being developed in a design-oriented educational research. This resulted in a multidisciplinary educational design game, which aims to facilitate cross-border communication, knowledge co-construction, and educational design processes during multidisciplinary educational design and improve the quality of the resulting multidisciplinary educational design.