A traditional anatomy lab using microscope slides to examine the structures of the integumentary system was enhanced to increase connections to the real world, student engagement, and interest in the topic by adding a forensic storyline where students examined structures of the integument in order to "solve the crime". Student perceptions regarding the addition of the storyline to the lab found that 88% of students reported that the storyline increased the connections they made between the lab and the real world. Eighty-six percent of students stated that the storyline increased their interest in the lab and 83% said that it made them more engaged in the lab. Sixty-three percent of students felt that the storyline helped them to learn the material better. A five-step strategy guided the conversion of a typical hands-on anatomy lab exercise into an engaging experience based on a storyline using materials commonly found in the lab. This strategy serves as a template to transform lab exercises into experiences that use both a storyline and a hands-on activity as drivers of student learning.