Objective: To examine the relative contribution of transition readiness (i.e., healthcare self-management) to health-related quality of life (HRQoL) among emerging adult (EA) college students without a chronic medical condition (CMC). Participants: College students (n = 2372; Mage = 19.32, SD = 1.26) from a Midwestern university. Methods: Participants completed online measures of demographics, HRQoL, and transition readiness. Results: Hierarchical regression analyses found transition readiness accounted an additional 3-4% of the variability in mental and physical HRQoL (p < 0.001), beyond demographic factors. 11.3% of EAs reported overall mastery of transition readiness, with navigating health insurance being the weakest area. Conclusions: Findings support the consensus that transition readiness is relevant to HRQoL for "all" EAs, including those without a CMC. EAs without a CMC demonstrate relatively weak transition readiness skills. Primary and university-based healthcare might consider programs supporting transition readiness and HRQoL among underresourced EAs.