Awareness and knowledge have been identified as essential requirements to successfully combat the global threat which COVID-19 currently poses. Rural communities are particularly at risk because of their low socio-economic status and high illiteracy level. There is currently uncertainty regarding how to effectively raise awareness about the pandemic and educate rural communities about it. In this study, we tested the effectiveness of interpersonal communication in awareness creation and knowledge about COVID-19 among rural communities in a developing country. We tested three hypotheses at 0.05 level of significance. The sample size was made up 470 participants. The questionnaire served as the instrument for data collection. In the analysis of data, both descriptive and inferential statistics were used. The results demonstrate that interpersonal communication is effective in creating awareness about COVID-19 among rural communities. It was also found that interpersonal communication was effective in improving knowledge about the pandemic among rural communications. We explored the implications of these findings on healthcare delivery.