This study evaluated whether interpersonal communication competence and public speaking anxiety had an impact on three indicators of student well-being (loneliness, belongingness, and flourishing) as well as evaluated whether the two most popular types of the introductory communication course (public speaking and hybrid/fundamentals) impacted interpersonal communication competence and public speaking anxiety to the same extent. Survey data was collected from 1378 students enrolled in one of these two introductory communication courses. Results showed that interpersonal communication competence was the strongest predictor of all three outcome variables, and public speaking anxiety predicted some additional variance in loneliness and belongingness, but not flourishing. Both types of courses significantly increased interpersonal communication competence and reduced public speaking anxiety, and there was no difference between the two course types in the extent to which they impacted those outcomes.