A leader with entrepreneurial skills facilitates students to be creative, innovative, and have entrepreneurship enthusiasm, to be ready to adapt to the working demands. The school principal's entrepreneurship commitment resolves the issues of the current working competition. Meanwhile, the school principal's entrepreneurship attitude based on "Wanua Mappatuo Naewai Alena" cultural value can be exclusive excellence that supports entrepreneurship education. This study seeks to contribute to local culture-based schools' entrepreneurship programs in shaping students' life skills and independence. This study employed a qualitative approach with a case study design. In-depth interviews, observation, and documentation were used to obtain the data, which were then analyzed through stages of data condensation, data presentation, and conclusion formulation. The data validity was investigated from the degree of trustworthiness, dependability, compatibility, and assertiveness. Finidngs from the study suggest that the principal's leadership strategy based on the cultural values of Wanua Mappatuo Naewai Alena has a positive impact on supporting entrepreneurship education in schools. The values contained in the "Wanua Mappatuo Naewai Alena" culture can unite in the souls of school principals, teachers, and students. Cultural values such as daring to face problems (Siri na Pacce), having an innovative spirit (Macca Na Malempu), working hard for school entrepreneurial success (Warani na Magetteng), entrepreneurial instincts and desires to make children independent (Sipakatau and Sipakalebbi), motivation entrepreneurship (Sipakingeng).