This article used a questionnaire survey for the college students on learning and teaching in epidemic situation. The result of the study shows that there were existing superficial understanding on Online learning, insufficient theoretical guidance for online teaching innovation and teaching support services still lag behind expectations. Based on the data of the questionnaire, putting forward a mixed online and offline teaching model hoping that the mode can stimulate students' interest in active learning, promote the interaction between teachers and students, enrich relevant research theories and to a certain extent improve students' ability to think independently and solve practical problems.