In this article, I present the results of a national study of response to student writing and argue for an approach to response I call "Responding for Transfer" (RFT). My corpus includes peer and teacher responses to 1,054 rough and final drafts of student writing from across the curriculum as well as 128 student self-reflection essays from ePortfolios at seventy institutions of higher education across the U.S. I present evidence from this corpus to support my argument for an RFT approach that emphasizes student self-assessment, focuses teacher response on student metacognition rather than the products of drafts, and takes response into consideration in the design of vertical transfer curriculum.