This study's aim is to determine whether or not medical students in Pakistan are willing to use online learning during the COVID-19 pandemic, as well as their perception of and satisfaction with online learning. The study also analyzed the relationship between technology-related stress and computer self-efficacy among medical students. This cross-sectional study selected 369 newly enrolled medical students as samples using convenience sampling. Medical students exhibited a significant negative association with technology-stress and the intention to use online learning. Further, computer self-efficacy decreased the effects of technology-stress and enhanced the intention to use online learning among medical students. Thematic analysis revealed three main themes: (1) engagement in studies, (2) management of time, and (3) challenges faced by students. Although students experienced challenges in terms of methodological, technological, and behavioral concerns during online classes, online classes also saved time and enhanced performance as a result of better time management.