The purpose of the study was to develop tailored messages for improving mental health and adjustment of Asian international students (AISs) in the United States. The PEN-3 cultural model was used to contextualize the role of culture in mental health needs of AISs. Applying a mixed method approach, the study developed messages through a multistep participatory process consisting of three focus groups (n = 15 participants), 13 individual interviews, one expert consultation, and an online survey (n = 85 responses). Data analysis led to the development of seven broad themes with seven tailored messages under each theme, including increasing the awareness of mental health and reducing stigma; motivational quotes; available and accessible resources for AISs to improve mental health; seeking help from social network and developing interpersonal skills; adjusting to American culture and college life; coping strategies to reduce stress and improve mental health and adjustment; and safety issues. The implications for culturally responsive programs are discussed.