Distance education provides rich opportunities for students in remote or rural areas attending tribal colleges and universities (TCUs) to pursue academic enhancement that contributes to career development. While many TCUs launched distance and online learning opportunities in early 2020, few were prepared with faculty training, development, or guidelines to ensure a rich student experience. This article provides a review of faculty roles and responsibilities in distance education, including both best practices for distance and online education offerings and strategies for instructor engagement throughout a distance delivery course.