The contemporary complex settings under which research and innovation (R&I) activities are executed in academic institutions calls for the definition of suitable management and administration approaches. To this end, (1) the existing literature on the management of R&I projects in the academia is reviewed; (2) major specificities of R&I projects are discussed; (3) recent trends in project management are addressed; and (4) a specific framework for the management of R&I projects in higher education is proposed. The proposed management framework is defined in eight pillars, namely: (1) clarification of scope and goals; (2) use of standards; (3) scalability and flexibility; (4) workflow modelling; (5) use of tools, techniques and templates; (6) existence of a "project board" or similar; (7) adequate risk management; and (8) organizational learning. The authors argue that it should be seen as a practical tool for university managers and administrators to apply a structured and comprehensive overview of key action areas that will increase the effectiveness, efficiency and impact of R&I project management and administration in academic contexts.