Each year, the NASP Assistance to States (ATS) committee hosts regional leadership meetings (RLM) as part of the annual convention. In November 2021, state leaders across the country joined forces to learn about the process of implementation science and how to facilitate sustainable change. At the core, implementation science examines critical factors and environments needed to ensure that sustainable practices are adopted and integrated into daily practice. This article reviews the why, what, who/where, and how of implementation science's "formula for success."