With widening application of systems modeling and simulation in healthcare industry, relevant courses have been created in many undergraduate biomedical engineering curricula to address the need in workforce development. However, it is challenging to teach systems modeling and simulation and effective teaching is demanded. To answer the call, I have used serious games in my teaching in the past few years. In this paper, I first present two interesting educational games and describe the design and implementation of two game-based active learning modules. I also report several learning outcome assessments and review my self-reflection during the teaching. Better game design and implementation, as well as further development of objective learning outcome assessments, are included in future plan.