Evaluation is crucial in the treatment of autistic children. The Psychoeducational Profile--Third Edition (PEP-3) is a standardized scale used to evaluate the development of children with autism spectrum disorder (ASD). However, as a traditional scale, the PEP-3 relies highly on the experience of the evaluator, and the evaluation process is complicated and time-consuming. Therefore, based on the PEP-3, this study aimed to use touchscreen and speech recognition technology to develop a set of human-computer interaction (HCI) games for the evaluation of the cognitive and language abilities of children with ASD. The study consisted of three parts: construct evaluation of the items and games, calibration and validation of the games, and cross-validation of the games. A total of 45 ASD children were recruited. They were divided into two groups: the calibration/validation group and the cross-validation group. The calibration/validation group was used to test the feasibility of the evaluation games. The cross-validation group was used to validate the effectiveness of the evaluation games. The results showed (1) the HCI evaluation games were a supportive tool to evaluate the cognitive and language ability of children with ASD; (2) there was a high agreement between the HCI evaluation games and the PEP-3, and the evaluation based on the HCI evaluation games reflected the evaluation results of the PEP-3; and (3) compared to the PEP-3, the HCI evaluation games saved time and were objective and attractive. Overall, our findings demonstrated that the HCI evaluation games were an effective means for evaluation and encourage future work in exploring technology-based methods for evaluating children with ASD.