In pediatric health care there is increasing attention for a child-centered approach, also referred to as personalized care (Coyne, Hallstrom, & Soderback, 2016). In this care it is essential to assess personal relevant functioning, hence, to explore which activities are important for a child and to assess the quality of performance of these meaningful activities (Coster & Khetani, 2008; Rodger & Kennedy-Behr, 2017). Therefore, health care providers need to ask children what they do or want to do and then assess the performance in their own context. However, how can providers ask children with multiple disabilities how they feel on the meaningfulness of activities? To provide personalized care and plan interventions that focus on meaningful activities insight is needed into the performance of meaningful activities in the daily living environment. Therefore, this case report describes whether the combined use of Talking Mats® and the Perceive, Recall, Plan and Perform-Assessment of home videos in a child with limited communication and cognitive abilities is feasible.