Much research has been executed to investigate how altering focus of attention impacts performance and feelings of fatigue. Using a within-participant design, the present study examined how an associative and dissociative attentional in addition to an internal and external attentional dimension influenced the running economy of nonprofessional runners. Twelve women (aged 18-30 years old) ran on a treadmill at 70% of their predetermined maximum velocity. Participants ran in four counterbalanced conditions (dissociative-external, dissociative-internal, associative-external, and associative-internal). Average oxygen volume, respiration volume and breathing frequency, heart rate, blood lactate level, and Borg rating of perceived exertion were measured. Our findings revealed when participants adopted a dissociative-external focus of attention, they consumed less oxygen, had lower blood lactate, and a lower rating of perceived exertion compared with trials completed using an associative attention strategy. The findings of this study demonstrate that running economy is improved and feelings of fatigue are lowest when using a combination of a dissociative-external focus of attention.