The ways caregivers perceive and respond to challenging behavior (CB) could depend, in part, on their cultural and ethnic backgrounds. Yet, limited research is available on the definitions, perceptions, and response strategies of CB across cultural groups, particularly among caregivers of young children with disabilities. In this exploratory multimethod study, data were collected from four diverse caregiver groups (i.e., Black, Korean American, Mexican American, and White) with young children with disabilities to understand (a) what behaviors they considered challenging and (b) how they responded to those behaviors. Data revealed similarities and differences in the types of behaviors reported and indicated caregivers rely on preplanned consequence strategies and unplanned responses.