The authors present a new classroom-tested lesson that was designed to engage students in the joy of mathematical inquiry through a card game, Frustration, while building number sense, understanding of uncertainty, statistical reasoning, and discourse skills. The purpose in developing and sharing these lessons is to highlight how games of chance can offer rich opportunities to teach probability and statistics for conceptual understanding in the middle grades. The lessons described allow students to explore probability with nonroutine inquiry and discourse, and intentionally included ways to use the teaching practices of Explicit Attention to Concepts and Student Opportunities to Struggle to further encourage students' understanding. These are difficult topics to fit into already packed curricula, so the multiple versions of the lesson are included to be useful to a wide range of teachers.