The 21st-century skills consist of life and career, study and innovation, and information technology skills. The ability to communicate and collaborate is one of the skills. Therefore, this study aims to determine the effect of communication and collaboration skills on the work readiness of vocational students. A total number of 350 students were used as respondents. Furthermore, the instruments used were Self-Perceived Communication Competence, Work Readiness scale and Teamwork Scale for Youth. The results showed that communication and collaboration skills had both partial and simultaneous influences on student work readiness. Also, these skills were directly proportional to the level of the vocational students' work readiness. In addition, the teacher was a factor that played a role in improving communication and collaboration skills in schools. Meanwhile, with intensive supervision, parents play a role in the improvement of these skills when students are outside the school.