Several previous studies showed that prime-target pairs with orthographical overlap but no semantic or morphological relationship (e.g., freeze-free) produced a masked priming effect in second language (L2) speakers but not in first language (L1) speakers. The present study further explored this intriguing L1-L2 difference by comparing English native speakers and nonnative speakers in the masked priming paradigm in combination with a lexical decision task. The stimuli included prime-target pairs with orthographical overlap at both the word-initial and word-final positions (e.g., rubber-rub, stage-age) but without any semantic or morphological relationship. The results replicated orthographic priming in L2 speakers for words with both overlap positions. Two accounts of this L1-L2 difference are discussed, one focusing on the representational aspect and the other on the processing characteristics of the L2 lexicon.