The paper explores the phenomenon of the local-worldly university. Why should we cultivate "the Difference" in everyday practices of the university? The author refers to the Derridean "différance," to the idea of wonder ([Greek characters omitted]) and the Herderean concept of "Heimat." By putting these terms in the university's specific context, the author asks questions about an autonomous space for thinking and experiencing. The university cannot be homeless, unanchored or uncommitted. The more intensively the universalising procedures of the control of universities are implemented, the more we are convinced that the world does not need any global institutions of higher education and research. This is because a human being is more localised than we would be willing to admit. What is important is difference, the untranslatability of knowledge and languages, the contextual grounding of thinking and action, as well as the experience of the fragility of what is "locally human," which makes us observe closely a local human being, attached to a place, wandering about with the notion of home, and thus dispelling his or her doubts here and now, even when they tend to recur eternally.