Objective: This study examined relationships between prosocial factors including altruism, compassion, social connectedness, spirituality, and volunteerism and measures of health in college students. Participants: A total of N = 1,075 participants from four institutions across various regions of the U.S. were included. Methods: Participants were sent email invitation via student listserv to participate in a survey of health and prosocial factors that was open for one month. Results: Hierarchical linear regressions were completed to examine the influence of prosocial variables on perceptions of health and engagement in health behaviors. Social connectedness was a significant contributor to variance in all health measures, and the variables with the most variance explained were symptoms of depression (28.6%) and Health-Related Quality of Life (24.6%). Conclusions: Institutions should prioritize programing to enhance social connectedness and other prosocial behaviors because of the positive effect these factors can have on health and health behaviors.