This was second year's research in developing a biology learning module of ecosystem material that promotes mobile android-based local region potentials, after first year conducted a field examination on android e-module and limited testing in East Lombok Regency, West Nusa Tenggara and Sleman Regency, D.I. Yogyakarta. The second-year research aimed to investigate the results of biology learning on local ecosystem material towards the development of scientific process skill and divergent thinking ability in Senior High School of Yogyakarta City and Sleman Regency. This module development followed a Design and Development Research approach. Data collecting technique used a posttest of scientific process and divergent thinking skills. Analysis technique were quantitative descriptives analysis. The result showed that the comparison of second year android module dissemination result towards the development of scientific process and divergent thinking skills of Senior High School students of Yogyakarta City and Sleman Regency showed a higher results in problem solving design than project based learning design, however, in z value of problem solving design obtained a value of -1,11, while in project based learning design obtained z value of 12,6. It meant there were other factors that influenced the android module application.