This quality review is an analysis of the methodological quality of social communication intervention research identifying which social communication interventions for this population could be considered evidence-based practices (EBPs). The purpose of the quality review was to apply the What Works Clearinghouse (WWC) guidelines to the literature of social communication interventions for individuals with autism spectrum disorder (ASD). The findings of this study found important issues that need to be considered in this field of social communication interventions for adolescents and adults with ASD in relation to the quality of the single-case experimental design (SCED). In addition, video modeling interventions have been established as an EBP of social communication intervention for this population.