Background: Although the link between substance use and criminal behavior is well-established, associations between the use of specific substances and specific criminal charges remains unclear. That is, there are mixed findings in the literature, and the majority of extant literature focuses only on associations between alcohol and marijuana use and a limited range of charges. Objective: The current study examined 30-day frequency of use of various substances (i.e., traditional tobacco, alcohol, marijuana, e-cigarettes, and prescription drugs) prior to detainment, percentages of youth charged with various offenses, and whether certain offenses were associated with more frequent use of particular substances prior to detainment among detained youth. Additionally, differences in substance-charge associations among Black and White youth were evaluated. Method: Detained youth (N = 235; 71.9% male; M age = 15.59 years) from two facilities self-reported on their substance use and the facilities provided charge data. Results: Marijuana was the most frequent substance used and violent-related offenses were the most common charge received. Interestingly, several charges (i.e., sex-, weapon-, and violent-related offenses) were associated with less frequent use of tobacco and/or marijuana use, but youth who were detained for non-criminal reasons (i.e., children in need of care) reported more frequent use of various substances than youth detained for criminal charges. Findings were more similar than different for Black and White youth, with very few differences evident. Conclusions: Children in need of care appear more at risk for certain substances than those detained for criminal offenses, with associations similar for detained Black and White youth.