Science and mathematics literacy are fundamental to the basic understanding of food and health and/or the pursuit of science-based careers. In 1999, the FoodMASTER Initiative (FMI) was created to provide an opportunity for youth to experience authentic, real-world health science activities in K-12 learning environments. FMI administrative locations have included Ohio University 1999-2005, East Carolina University 2006-2018 and Northern Illinois University 2018-current. The key programmatic elements for the FMI include: (1) curricular hands-on activities developed with teacher input; (2) free online access; (3) rigorous evaluation of program materials; and (4) robust partnerships with organizations that promote mathematics and science education. The purpose of this manuscript will be to: (1) provide a rationale for the FMI programming; (2) share the curriculum and the process for developing curriculum and summarize the quantitative and qualitative findings of the 19 peer-reviewed articles; (3) discuss funding that was secured; (4) discuss strategies that lead to program sustainability; (5) discuss the mission and vision; and (6) summarize programmatic component sustainability.